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Scientific Manager : Olivier Lafon (This email address is being protected from spambots. You need JavaScript enabled to view it.)
Operational Manager : François-Xavier Cantrelle (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Center for Catalysis and Solid State Chemistry /
Center for Structural and Functional Glycobiology

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Lille High Field NMR platform comprises  800 MHz and 900 MHz NMR spectrometers equipped for both liquid- and solid-state NMR. They are locally managed by  the Center for Catalysis and Solid State Chemistry (Unité de Catalyse et de Chimie du Solide, UCCS, UMR- 8181 CNRS/Univ. Lille/ENSC-Lille/EC-Lille/Univ. Artois) and the Center for Structural and Functional Glycobiology (Unité de Glycobiologie Structurale et Fonctionnelle, UGSF, UMR-8576 CNRS/Univ. Lille). UCCS and UGSF are respectively involved in research clusters FR 2638 (Institut Michel-Eugène Chevreul) and FR 3688 (FRABio, Biochimie Structurale et Fonctionnelle des Assemblages Biomoléculaires) that bring together most of the analytical platforms for Chemistry and Biology at the University of Lille.

Description of the high-field NMR platform

 Spectrometers :
+ 800SB [Solid(75%)/Liquid+HR-MAS(25%)]
+ 900SB [Liquid with cryoprobe (75%)/solid+liquid+HR-MAS (25%)]

900MHz spectrometer is used with the cryoprobe 75 % of the time with two sessions per year of 6-8 weeks long dedicated to "warm  probes" (solid state/broadband liquid state NMR).
On 800 MHz spectrometer, liquid/solid state probes are exchanged on demand.

900 MHz spectrometer with 4 channels Avance III console

SampleJet for automatic sample changer (controled temperature loader tray : 6°C, 16°C, Room temp.)
BCU-X for temperature regulation in solids

Liquid state probes:
CryoProbe TCI (1H*, 13C*, 15N, 2H*), 5 mm, z-gradient, T: -40 to 80 °C (*cold  channels)
HR-MAS probe 4mm (1H/13C/15N/2H) z-gradient, T: +2 to +50°C
BBO probe 5mm, z-gradient, Tº : -150 to 180 °C, 109Ag-31P
TXI probe 5mm (1H, 13C, 15N, 2H), 5 mm, z-gradients, T: -150 to 150 °C
Solid state probes:
HX probe 7mm VTN bas-gamma (143Nd-15N)
HX probe DVT 2,5mm (14N-31P)
HX probe DVT 1.3mm (14N-31P) [note: cannot tune1H when X tuned to 31P ]
HCN probe VTN 3.2mm (1 H/ 13 C / 15 N)

800 MHz spectrometer with 4 channels Avance III console

A frequency splitter (REDORBOX manufactured by NMR-Service company) can be used with the 3.2 mm HX probe in order to carry out double-resonance NMR experiments between isotopes with close Larmor frequencies near 200 MHz, such as 3C,27Al,23Na and 51V.

Liquid-state / HRMAS probe:
HR-MAS 4mm (1H/13C/15N/2H) probe z-gradient, T: 2 to 50 °C
HR-MAS 4mm (1H/13C/31P/2H) probe z-gradient, T: 2 to 50 °C
BBI 3mm (1H/BB/2H) probe, z-gradient, T: -150 à 180°C
TXI 5mm (1H, 13C, 15N, 2H) probe, z-gradient, T: -50 à 80°C
Solid-state probe:
Novel probe : 3.2mm DVT HX (15N – 31P) probe
4mm HX (187W – 65Cu) probe with Revolution NMR rotors
3.2mm DVT HX (187W – 65Cu) probe
3.2mm VTN BP (31P / 71Ga,11B,115Sn,87Rb) probe with VESPEL stator (free of 11B background signal)
3.2mm DVT tri-Gamma® HXY probe (dedicated to 1H-13C-14N)
3.2mm DVT tri-Gamma® HXY probe (dedicated to 1H-11B-29Si)
2 3.2mm DVT tri-Gamma® HXY probe (X=31P-13C, Y=15N-29Si but there are restrictions for the possible correlations: for instance, Y=29Si is only possible if X=31P)
3.2mm DVT HPX (1H, 31P, X=93Nb, 51V-23Al) probe
2.5mm DVT tri-Gamma® HXY probe (X=31P-13C, Y=15N-29Si ut there are restrictions for the possible correlations)
HX DVT 1.3mm (14N-31P) probe

photoFeasible NMR experiments:

Solid-state NMR : high-resolution NMR experiments for quadrupolar nuclei (MQ-MAS, ST-MAS), through-space and through-bond hetero- and homo-nuclear correlations between spin-1/2 isotopes and quadrupolar nuclei (notably homonuclear correlation between half-integer spin quadrupolar nuclei, HMQC or INEPT correlation between spin-1/2 isotopes and quadrupolar nuclei, including those with close Larmor frequencies, such as 13C-27Al …), high-resolution 1H NMR experiments...

Research activities:

RM2I-UCCS :

The research group about NMR and inorganic materials (RM2I) at UCCS focuses on the development of solid-state NMR methods, notably at high magnetic fields and for quadrupolar nuclei. In particular, this group has developed hetero-nuclear correlation methods involving quadrupolar nuclei and has applied these techniques for the characterization of oxide glasses and heterogeneous catalysts (group web page).

UGSF :

Other NMR instruments in Lille :

Besides 800 and 900 MHz NMR spectrometers, the Lille NMR cluster brings together NMR research groups from UCCS, UGSF, LARMN and LASIR as well as the lower field NMR spectrometers located near Lille. These spectrometers belong to the NMR facilities of the Departments of Chemistry and Pharmacy at the University of Lille as well as to the NMR facility of the Pasteur Institute of Lille.

Solid-state NMR spectrometers of the Department of Chemistry at the University of Lille:

  • Two 400 MHz WB NMR spectrometers:

    • the probes can be used on both spectrometers:

      • triple resonance (2.5mm, 3.2mm, 4mm) probe;

      • 4mm HX (standard CPMAS, bas gamma, WVT, MQMAS) probe;

      • 7mm HX bas gamma probe.

    • REDOR Box with a nominal frequency of 100 MHz (13C-23Na).

  • 100 MHz WB spectrometer with 2 channels:

    • 4mm HX CPMAS probe;

    • 7 mm HX CPMAS probe.

Liquid-state NMR spectrometers of the Department of Chemistry at the University of Lille:

  • 400 MHz SB spectrometer equipped with Avance II console:

    • 5 mm BBO (BB/1H/2H) probe, z-gradient, T: -150 to +150 °C;

    • 5 mm BBI (1H/BB/2H) probe, z-gradient, T: -150 to +150 °C;

    • 5 mm TBI (1H/13C/BB/2H) probe, z-gradient, T: -150 to +150 °C;

    • 10 mm BBO (BB/1H/2H) probe, T: -150 to +150 °C.

  • 300 MHz SB spectometer equipped with Avance console and express sample changer (60 positions):

    • 5 mm BBFO probe, z-gradient;

    • 5 mm QNP (1H, 19F, 13C, 31P) probe, z-gradient.

Liquid-state NMR spectrometers at Pasteur Institute of Lille :

  • 600MHz SB spectrometer equipped with Avance console and BACS sample changer (60 positions):

    • QCI (1H*, 19F*, 13C*, 15N, 2H*) cryoprobe, 5 mm, z-gradient, T: 0 to +80 °C (*cold channels).

  • 300MHz SB spectrometer equipped with DRX console:

    • 5 mm BBI (1H,BB [31P,109Ag]) probe, z-gradient, T: -80 to +120 °C;

    • 5 mm HR-MAS (1H,13C,2H) probe, z-gradient, T: +2 to +50 °C.

Liquid-state NMR spectrometers of the Department of Pharmacy at the University of Lille:

  • 500 MHz SB spectrometer equipped with Avance console:

    • 5 mm TXI (1H, 13C, 15N, 2H) probe, z-gradient;

    • 5 mm QNP (1H, 19F, 13C, 31P, 2H) probe, z-gradient;

    • 5 mm BBO (BB/1H/2H) probe, z-gradient;

    • 4 mm HR-MAS (1H/13C/2H) probe, z-gradient;

    • NMR measurements under light irradiation via an optical fiber [mercury-vapor lamp with filters, Nd:YAG laser with wavelengths 532, 355 et 266 nm].

  • 300 MHz SB spectrometer equipped with Avance console:

    • BBI probe (1H/BB/2H) probe, z-gradient;

    • QNP probe (1H, 19F, 13C, 31P, 2H) probe, z-gradient;

    • express lite sample changer with 16 positions.
  • 300 MHz SB spectrometer equipped with Avance console:

    • BBFO probe, z-gradient;

    • express lite sample changer with 16 positions.